Nicotine Induces Resistance to Erlotinib Therapy in Non-Small-Cell Lung Cancer Cells Treated with Serum from Human Patients

Nicotine Induces Resistance to Erlotinib Therapy in Non-Small-Cell Lung Cancer Cells Treated with Serum from Human Patients

Previously, we reported that nicotine reduces erlotinib sensitivity in a xenograft model of PC9, an epidermal growth factor receptor-tyrosine kinase inhibitor (EGFR-TKI)-sensitive non-small-cell lung cancer cell line. The present study examined whether smoking induces erlotinib resistance in vitro....

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Bibliographic Details
Main Authors: Tatsuya Imabayashi, Junji Uchino, Hisayuki Osoreda, Keiko Tanimura, Yusuke Chihara, Nobuyo Tamiya, Yoshiko Kaneko, Tadaaki Yamada, Koichi Takayama
Format: Article
Language:English
Published: MDPI AG 2019-02-01
Series:Cancers
Subjects:
cotinine
nicotine
non-small-cell lung cancer (NSCLC)
EGFR
erlotinib resistance
Online Access:https://www.mdpi.com/2072-6694/11/3/282

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https://www.mdpi.com/2072-6694/11/3/282

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