Altered expression of insulin‐degrading enzyme and regulator of calcineurin in the rat intracerebral streptozotocin model and human apolipoprotein E‐ε4–associated Alzheimer's disease

Altered expression of insulin‐degrading enzyme and regulator of calcineurin in the rat intracerebral streptozotocin model and human apolipoprotein E‐ε4–associated Alzheimer's disease

Abstract Introduction This study assesses insulin‐degrading enzyme (IDE) and regulator of calcineurin 1 (RCAN1) as potential mediators of brain insulin deficiency and neurodegeneration in experimental and human Alzheimer's disease (AD). Methods Temporal lobes from Long Evans rats treated with i...

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Bibliographic Details
Main Authors: Büşra Delikkaya, Natalia Moriel, Ming Tong, Gina Gallucci, Suzanne M. de laMonte
Format: Article
Language:English
Published: Wiley 2019-12-01
Series:Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring
Subjects:
Alzheimer's disease
Insulin deficiency
Insulin resistance
Streptozotocin
Insulin‐degrading enzyme
RCAN1
Online Access:https://doi.org/10.1016/j.dadm.2019.03.004

Internet

https://doi.org/10.1016/j.dadm.2019.03.004

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