Biological and epigenetic alterations of mitochondria involved in cellular replicative and hydrogen peroxide-induced premature senescence of human embryonic lung fibroblasts

Biological and epigenetic alterations of mitochondria involved in cellular replicative and hydrogen peroxide-induced premature senescence of human embryonic lung fibroblasts

The mitoepigenetic modifications may be closely related to cellular fate. Both the replicative and hydrogen peroxide (H2O2)-induced premature senescence models were used to detect the mitochondrial biological characteristics and the epigenetic factors during senescence of human embryonic lung fibrob...

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Bibliographic Details
Main Authors: Yan Wang, Jianji Gao, Fan Wu, Caiyun Lai, Yueqi Li, Gaoqiang Zhang, Xinyue Peng, Susu Yu, Jiani Yang, Wei Wang, Wenjuan Zhang, Xingfen Yang
Format: Article
Language:English
Published: Elsevier 2021-06-01
Series:Ecotoxicology and Environmental Safety
Subjects:
Human embryonic lung fibroblast
Premature senescence
Mitochondrial DNA
Methylation
Mitochondrial DNMT1
Online Access:http://www.sciencedirect.com/science/article/pii/S0147651321003158

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http://www.sciencedirect.com/science/article/pii/S0147651321003158

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