Nucleolin Rescues TDP-43 Toxicity in Yeast and Human Cell Models

Nucleolin Rescues TDP-43 Toxicity in Yeast and Human Cell Models

TDP-43 is a nuclear protein involved in pivotal processes, extensively studied for its implication in neurodegenerative disorders. TDP-43 cytosolic inclusions are a common neuropathologic hallmark in amyotrophic lateral sclerosis (ALS) and related diseases, and it is now established that TDP-43 misf...

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Bibliographic Details
Main Authors: Caterina Peggion, Maria Lina Massimino, Roberto Stella, Raissa Bortolotto, Jessica Agostini, Arianna Maldi, Geppo Sartori, Fiorella Tonello, Alessandro Bertoli, Raffaele Lopreiato
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-04-01
Series:Frontiers in Cellular Neuroscience
Subjects:
neurodegenerative disorders
TDP-43 proteinopathies
ALS
FTD
nucleolin
misfolded proteins
Online Access:https://www.frontiersin.org/articles/10.3389/fncel.2021.625665/full

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https://www.frontiersin.org/articles/10.3389/fncel.2021.625665/full

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