Fish-hunting cone snail venoms are a rich source of minimized ligands of the vertebrate insulin receptor

Fish-hunting cone snail venoms are a rich source of minimized ligands of the vertebrate insulin receptor

The fish-hunting marine cone snail Conus geographus uses a specialized venom insulin to induce hypoglycemic shock in its prey. We recently showed that this venom insulin, Con-Ins G1, has unique characteristics relevant to the design of new insulin therapeutics. Here, we show that fish-hunting cone s...

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Bibliographic Details
Main Authors: Peter Ahorukomeye, Maria M Disotuar, Joanna Gajewiak, Santhosh Karanth, Maren Watkins, Samuel D Robinson, Paula Flórez Salcedo, Nicholas A Smith, Brian J Smith, Amnon Schlegel, Briony E Forbes, Baldomero Olivera, Danny Hung-Chieh Chou, Helena Safavi-Hemami
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2019-02-01
Series:eLife
Subjects:
cone snail
venom
insulin
hypoglycemic shock
prey capture
diabetes
Online Access:https://elifesciences.org/articles/41574

Internet

https://elifesciences.org/articles/41574

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