Oxygen-independent stabilization of hypoxia inducible factor (HIF)-1 during RSV infection.

BACKGROUND: Hypoxia-inducible factor 1 (HIF)-1alpha is a transcription factor that functions as master regulator of mammalian oxygen homeostasis. In addition, recent studies identified a role for HIF-1alpha as transcriptional regulator during inflammation or infection. Based on studies showing that...

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Bibliographic Details
Main Authors: Helene A Haeberle, Carin Dürrstein, Peter Rosenberger, Yashoda M Hosakote, Johannes Kuhlicke, Volkhard A J Kempf, Roberto P Garofalo, Holger K Eltzschig
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2008-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2556398?pdf=render