TLR9 Binding to Beclin 1 and Mitochondrial SIRT3 by a Sodium-Glucose Co-Transporter 2 Inhibitor Protects the Heart from Doxorubicin Toxicity

TLR9 Binding to Beclin 1 and Mitochondrial SIRT3 by a Sodium-Glucose Co-Transporter 2 Inhibitor Protects the Heart from Doxorubicin Toxicity

Large cardiovascular outcome trials have reported favorable effects of sodium-glucose co-transporter 2 (SGLT2) inhibitors on heart failure. To study the potential mechanism of the SGLT2 inhibition in heart failure, we used the murine doxorubicin-induced cardiomyopathy model and identified the toll-l...

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Bibliographic Details
Main Authors: Chao-Yung Wang, Chun-Chi Chen, Mei-Hsiu Lin, Hui-Ting Su, Ming-Yun Ho, Jih-Kai Yeh, Ming-Lung Tsai, I-Chang Hsieh, Ming-Shien Wen
Format: Article
Language:English
Published: MDPI AG 2020-10-01
Series:Biology
Subjects:
SGLT2 inhibitor
doxorubicin
TLR9
SIRT3
Beclin 1
empagliflozin
Online Access:https://www.mdpi.com/2079-7737/9/11/369

Internet

https://www.mdpi.com/2079-7737/9/11/369

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