Relevant mediators involved in and therapies targeting the inflammatory response induced by activation of the NLRP3 inflammasome in ischemic stroke

Relevant mediators involved in and therapies targeting the inflammatory response induced by activation of the NLRP3 inflammasome in ischemic stroke

Abstract The nucleotide-binding oligomerization domain (NOD)-like receptor (NLR) family pyrin domain-containing 3 (NLRP3) inflammasome is a member of the NLR family of inherent immune cell sensors. The NLRP3 inflammasome can detect tissue damage and pathogen invasion through innate immune cell senso...

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Bibliographic Details
Main Authors: Qingxue Xu, Bo Zhao, Yingze Ye, Yina Li, Yonggang Zhang, Xiaoxing Xiong, Lijuan Gu
Format: Article
Language:English
Published: BMC 2021-05-01
Series:Journal of Neuroinflammation
Subjects:
NLRP3 inflammasome
Ischemic stroke
Inflammation
Reactive oxygen species
Signaling pathway
Online Access:https://doi.org/10.1186/s12974-021-02137-8

Internet

https://doi.org/10.1186/s12974-021-02137-8

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