MiniCD4 protein resistance mutations affect binding to the HIV-1 gp120 CD4 binding site and decrease entry efficiency

MiniCD4 protein resistance mutations affect binding to the HIV-1 gp120 CD4 binding site and decrease entry efficiency

<p>Abstract</p> <p>Background</p> <p>Binding of the viral envelope protein (Env), and particularly of its gp120 subunit, to the cellular CD4 receptor is the first essential step of the HIV-1 entry process. The CD4 binding site (CD4bs) of gp120, and especially a recessed...

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Bibliographic Details
Main Authors: Grupping Katrijn, Selhorst Philippe, Michiels Johan, Vereecken Katleen, Heyndrickx Leo, Kessler Pascal, Vanham Guido, Martin Loïc, Ariën Kevin K
Format: Article
Language:English
Published: BMC 2012-05-01
Series:Retrovirology
Subjects:
HIV-1
Resistance
Entry inhibitors
CD4 binding site
Entry efficiency
Online Access:http://www.retrovirology.com/content/9/1/36

Internet

http://www.retrovirology.com/content/9/1/36

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