The Genetic Architecture of Chronic Mountain Sickness in Peru

The Genetic Architecture of Chronic Mountain Sickness in Peru

Chronic mountain sickness (CMS) is a pathological condition resulting from chronic exposure to high-altitude hypoxia. While its prevalence is high in native Andeans (>10%), little is known about the genetic architecture of this disease. Here, we performed the largest genome-wide association s...

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Bibliographic Details
Main Authors: Steven Gazal, Jose R. Espinoza, Frédéric Austerlitz, Dominique Marchant, Jose Luis Macarlupu, Jorge Rodriguez, Hugo Ju-Preciado, Maria Rivera-Chira, Olivier Hermine, Fabiola Leon-Velarde, Francisco C. Villafuerte, Jean-Paul Richalet, Laurent Gouya
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-07-01
Series:Frontiers in Genetics
Subjects:
chronic mountain sickness (CMS)
GWAS—genome-wide association study
high altitude adaptation
natural selection
Monge’s disease
Online Access:https://www.frontiersin.org/article/10.3389/fgene.2019.00690/full

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https://www.frontiersin.org/article/10.3389/fgene.2019.00690/full

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