Astrocytes and microglia but not neurons preferentially generate N-terminally truncated Aβ peptides

Astrocytes and microglia but not neurons preferentially generate N-terminally truncated Aβ peptides

The neuropathological hallmarks of Alzheimer's disease include extracellular neuritic plaques and neurofibrillary tangles. The neuritic plaques contain β-amyloid peptides (Aβ peptides) as the major proteinaceous constituent and are surrounded by activated microglia and astrocytes as well as dys...

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Bibliographic Details
Main Authors: Timo Jan Oberstein, Philipp Spitzer, Hans-Wolfgang Klafki, Philipp Linning, Florian Neff, Hans-Joachim Knölker, Piotr Lewczuk, Jens Wiltfang, Johannes Kornhuber, Juan Manuel Maler
Format: Article
Language:English
Published: Elsevier 2015-01-01
Series:Neurobiology of Disease
Subjects:
N-terminally truncated
Aβ
Alzheimer's disease
Neurons
Astrocytes
Microglia
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996114002629

Internet

http://www.sciencedirect.com/science/article/pii/S0969996114002629

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