mRNA stem-loops can pause the ribosome by hindering A-site tRNA binding

mRNA stem-loops can pause the ribosome by hindering A-site tRNA binding

Although the elongating ribosome is an efficient helicase, certain mRNA stem-loop structures are known to impede ribosome movement along mRNA and stimulate programmed ribosome frameshifting via mechanisms that are not well understood. Using biochemical and single-molecule Förster resonance energy tr...

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Bibliographic Details
Main Authors: Chen Bao, Sarah Loerch, Clarence Ling, Andrei A Korostelev, Nikolaus Grigorieff, Dmitri N Ermolenko
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2020-05-01
Series:eLife
Subjects:
ribosome
translation
mRNA
smFRET
cryo-EM
Online Access:https://elifesciences.org/articles/55799

Internet

https://elifesciences.org/articles/55799

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