Acetamidine-Based iNOS Inhibitors as Molecular Tools to Counteract Inflammation in BV2 Microglial Cells

Acetamidine-Based iNOS Inhibitors as Molecular Tools to Counteract Inflammation in BV2 Microglial Cells

Neurodegenerative diseases are associated with increased levels of nitric oxide (NO) mainly produced by microglial cells through inducible nitric oxide synthase (iNOS) whose expression is induced by inflammatory stimuli. NO can both exert cytotoxic functions and induce a metabolic switch by inhibiti...

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Bibliographic Details
Main Authors: Silvia Grottelli, Rosa Amoroso, Lara Macchioni, Fiorella D’Onofrio, Katia Fettucciari, Ilaria Bellezza, Cristina Maccallini
Format: Article
Language:English
Published: MDPI AG 2020-06-01
Series:Molecules
Subjects:
acetamidine
iNOS inhibitor
nitric oxide
inflammation
pyruvate kinase M2
glycolytic enzymes
Online Access:https://www.mdpi.com/1420-3049/25/11/2646

Internet

https://www.mdpi.com/1420-3049/25/11/2646

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