The Potential Antipyretic Mechanism of Gardeniae Fructus and Its Heat-Processed Products With Plasma Metabolomics Using Rats With Yeast-Induced Fever

The Potential Antipyretic Mechanism of Gardeniae Fructus and Its Heat-Processed Products With Plasma Metabolomics Using Rats With Yeast-Induced Fever

Gardeniae Fructus (GF), prepared GF (GFP), and carbonized GF (GFC) are widely used in China for the treatment of fever. However, the involved antipyretic mechanism has not been fully elucidated. In this study, rectal temperature and pyrogenic cytokines were used to evaluate the antipyretic effect of...

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Bibliographic Details
Main Authors: Xue Zhang, Yun Wang, Shaojing Li, Yejia Dai, Xiaoqing Li, Qinghao Wang, Guoyou Wang, Yinlian Ma, Xuezhu Gu, Cun Zhang
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-05-01
Series:Frontiers in Pharmacology
Subjects:
metabolomics
Gardeniae Fructus
antipyretic
processed
ultra-high-performance liquid chromatography/mass spectrometry
multivariate statistical analysis
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2019.00491/full

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https://www.frontiersin.org/article/10.3389/fphar.2019.00491/full

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