HCV causes chronic endoplasmic reticulum stress leading to adaptation and interference with the unfolded protein response.

HCV causes chronic endoplasmic reticulum stress leading to adaptation and interference with the unfolded protein response.

BACKGROUND: The endoplasmic reticulum (ER) is the cellular site for protein folding. ER stress occurs when protein folding capacity is exceeded. This stress induces a cyto-protective signaling cascades termed the unfolded protein response (UPR) aimed at restoring homeostasis. While acute ER stress i...

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Bibliographic Details
Main Authors: Emmanuelle Merquiol, Dotan Uzi, Tobias Mueller, Daniel Goldenberg, Yaakov Nahmias, Ramnik J Xavier, Boaz Tirosh, Oren Shibolet
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3176279?pdf=render

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http://europepmc.org/articles/PMC3176279?pdf=render

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