Exome sequencing identifies frequent genomic loss of TET1 in IDH-wild-type glioblastoma

Exome sequencing identifies frequent genomic loss of TET1 in IDH-wild-type glioblastoma

Glioblastoma (GBM) is the most common and malignant brain tumor in adults. Genomic and epigenomic alterations of multiple cancer-driving genes are frequent in GBM. To identify molecular alterations associated with epigenetic aberrations, we performed whole exome sequencing-based analysis of DNA copy...

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Bibliographic Details
Main Authors: Sebastian Stasik, Tareq A. Juratli, Andreas Petzold, Sven Richter, Amir Zolal, Gabriele Schackert, Andreas Dahl, Dietmar Krex, Christian Thiede
Format: Article
Language:English
Published: Elsevier 2020-12-01
Series:Neoplasia: An International Journal for Oncology Research
Subjects:
Glioblastoma (GBM)
Next-generation sequencing (NGS)
Copy number variation (CNV)
IDH
TET1 deletion
EGFR amplification
Online Access:http://www.sciencedirect.com/science/article/pii/S1476558620301652

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http://www.sciencedirect.com/science/article/pii/S1476558620301652

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