Studies on Synthesis and Structure-Activity Relationship (SAR) of Derivatives of a New Natural Product from Marine Fungi as Inhibitors of Influenza Virus Neuraminidase

Studies on Synthesis and Structure-Activity Relationship (SAR) of Derivatives of a New Natural Product from Marine Fungi as Inhibitors of Influenza Virus Neuraminidase

Based on the natural isoprenyl phenyl ether from a mangrove-derived fungus, 32 analogues were synthesized and evaluated for inhibitory activity against influenza H1N1 neuraminidase. Compound 15 (3-(allyloxy)-4-hydroxybenzaldehyde) exhibited the most potent inhibitory activity, with IC50 values of 26...

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Bibliographic Details
Main Authors: Yongcheng Lin, Jiyan Pang, Shu Liu, Mengfeng Li, Dingmei Zhang, Xun Zhu, Zhenjian He, Jing Li
Format: Article
Language:English
Published: MDPI AG 2011-10-01
Series:Marine Drugs
Subjects:
aromatic ether
marine fungus
neuraminidase inhibitor
Online Access:http://www.mdpi.com/1660-3397/9/10/1887/

Internet

http://www.mdpi.com/1660-3397/9/10/1887/

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