Synthesis of Sterically Protected Isoindoles from ortho-Phthalaldehyde

Synthesis of Sterically Protected Isoindoles from ortho-Phthalaldehyde

Abstract o-Phthalaldehyde (OPA) reacts with O-protected tris(hydroxyalkyl)aminomethanes in the presence of 1-propanethiol to afford a novel class of stable isoindoles. Steric protection provided by the bulkiness of C 3-symmetric primary amines derived from tris(hydroxymethyl...

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Bibliographic Details
Main Authors: Michiyasu Nakao, Nanako Nishikiori, Akihito Nakamura, Murasaki Miyagi, Nao Shibata, Syuji Kitaike, Makoto Fukui, Hiro-O Ito, Shigeki Sano
Format: Article
Language:English
Published: Georg Thieme Verlag KG 2018-01-01
Series:SynOpen
Subjects:
o-phthalaldehyde
isoindole
steric protection
isoindolin-1-one
Online Access:http://www.thieme-connect.de/DOI/DOI?10.1055/s-0036-1591932

Internet

http://www.thieme-connect.de/DOI/DOI?10.1055/s-0036-1591932

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