Colorectal cancers mimic structural organization of normal colonic crypts.

Colonic crypts are stereotypical structures with distinct stem cell, proliferating, and differentiating compartments. Colorectal cancers derive from colonic crypt epithelia but, in contrast, form morphologically disarrayed glands. In this study, we investigated to which extent colorectal cancers phe...

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Bibliographic Details
Main Authors: Laura Cernat, Cristina Blaj, Rene Jackstadt, Lydia Brandl, Jutta Engel, Heiko Hermeking, Andreas Jung, Thomas Kirchner, David Horst
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4128715?pdf=render