Axonal damage and loss of connectivity in nigrostriatal and mesolimbic dopamine pathways in early Parkinson's disease

Axonal damage and loss of connectivity in nigrostriatal and mesolimbic dopamine pathways in early Parkinson's disease

A progressive loss of dopamine neurons in the substantia nigra (SN) is considered the main feature of idiopathic Parkinson's disease (PD). Recent neuropathological evidence however suggests that the axons of the nigrostriatal dopaminergic system are the earliest target of α-synuclein accumulati...

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Bibliographic Details
Main Authors: Silvia Paola Caminiti, Luca Presotto, Damiano Baroncini, Valentina Garibotto, Rosa Maria Moresco, Luigi Gianolli, Maria Antonietta Volonté, Angelo Antonini, Daniela Perani
Format: Article
Language:English
Published: Elsevier 2017-01-01
Series:NeuroImage: Clinical
Subjects:
Parkinson's disease
Positron emission tomography
Dopamine transporter
Axonal damage
Molecular connectivity
Online Access:http://www.sciencedirect.com/science/article/pii/S2213158217300712

Internet

http://www.sciencedirect.com/science/article/pii/S2213158217300712

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