Blockade of the programmed death-1 (PD1) pathway undermines potent genetic protection from type 1 diabetes.

Blockade of the programmed death-1 (PD1) pathway undermines potent genetic protection from type 1 diabetes.

Inhibition of PD1-PDL1 signaling in NOD mice accelerates onset of type 1 diabetes implicating this pathway in suppressing the emergence of pancreatic beta cell reactive T-cells. However, the molecular mechanism by which PD1 signaling protects from type 1 diabetes is not clear. We hypothesized that d...

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Bibliographic Details
Main Authors: Nora M Kochupurakkal, Annie J Kruger, Sudipta Tripathi, Bing Zhu, La Tonya Adams, Daniel B Rainbow, Aldo Rossini, Dale L Greiner, Mohamed H Sayegh, Linda S Wicker, Indira Guleria
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3938467?pdf=render

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http://europepmc.org/articles/PMC3938467?pdf=render

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