ctDNA Clearance and Radiographic Resolution of Disease in Response to Dual Checkpoint Inhibition in Metastatic Microsatellite Stable Colorectal Cancer with a High Tumor Mutation Burden

ctDNA Clearance and Radiographic Resolution of Disease in Response to Dual Checkpoint Inhibition in Metastatic Microsatellite Stable Colorectal Cancer with a High Tumor Mutation Burden

Immunotherapy (IO) has increasingly been demonstrated to provide therapeutic benefit to patients with metastatic colorectal cancer (mCRC). However, only a subset of mCRC tumors respond to IO. Monitoring response with tumor biomarkers like carcinoembryonic antigen (CEA) has been challenging in patien...

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Bibliographic Details
Main Authors: Charles J. Schneider, Michael Krainock, Allyson Koyen Malashevich, Meenakshi Malhotra, Perry Olshan, Paul R. Billings, Alexey Aleshin
Format: Article
Language:English
Published: Karger Publishers 2021-06-01
Series:Case Reports in Oncology
Subjects:
metastatic colorectal cancer
circulating tumor dna
carcinoembryonic antigen
noninvasive biomarkers
microsatellite instability high
immunotherapy
Online Access:https://www.karger.com/Article/FullText/516190

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https://www.karger.com/Article/FullText/516190

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