Aminodi(hetero)arylamines in the Thieno[3,2-b]pyridine Series: Synthesis, Effects in Human Tumor Cells Growth, Cell Cycle Analysis, Apoptosis and Evaluation of Toxicity Using Non-Tumor Cells

Aminodi(hetero)arylamines in the Thieno[3,2-b]pyridine Series: Synthesis, Effects in Human Tumor Cells Growth, Cell Cycle Analysis, Apoptosis and Evaluation of Toxicity Using Non-Tumor Cells

Three aminodi(hetero)arylamines were prepared via a palladium-catalyzed C-N Buchwald-Hartwig coupling of methyl 3-aminothieno[3,2-b]pyridine-2-carboxylate with different bromonitrobenzenes, followed by reduction of the nitro groups of the coupling products to the corresponding amino compounds. The a...

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Bibliographic Details
Main Authors: M. Helena Vasconcelos, M. Inês Alvelos, Raquel T. Lima, Eugénia Pinto, Luís A. Vale-Silva, Rui M. V. Abreu, Isabel C. F. R. Ferreira, Daniela Peixoto, Ricardo C. Calhelha, Maria-João R. P. Queiroz
Format: Article
Language:English
Published: MDPI AG 2012-03-01
Series:Molecules
Subjects:
thieno[3,2-b]pyridines
aminodi(hetero)arylamines
Buchwald-Hartwig C-N coupling
antitumoral activity
toxicity
cell cycle
apoptosis
Online Access:http://www.mdpi.com/1420-3049/17/4/3834/

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http://www.mdpi.com/1420-3049/17/4/3834/

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