Mast Cells and MCPT4 Chymase Promote Renal Impairment after Partial Ureteral Obstruction

Mast Cells and MCPT4 Chymase Promote Renal Impairment after Partial Ureteral Obstruction

Obstructive nephropathy constitutes a major cause of pediatric renal progressive disease. The mechanisms leading to disease progression are still poorly understood. Kidney fibrotic lesions are reproduced using a model of partial unilateral ureteral obstruction (pUUO) in newborn mice. Based on data s...

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Bibliographic Details
Main Authors: Maguelonne Pons, Liza Ali, Walid Beghdadi, Luca Danelli, Marianne Alison, Lydia Celia Madjène, Jessica Calvo, Julien Claver, Shamila Vibhushan, Magnus Åbrink, Gunnar Pejler, Marie-Laurence Poli-Mérol, Michel Peuchmaur, Alaa El Ghoneimi, Ulrich Blank
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-05-01
Series:Frontiers in Immunology
Subjects:
mast cells
chymase
hydronephrosis
fibrosis
inflammation
Online Access:http://journal.frontiersin.org/article/10.3389/fimmu.2017.00450/full

Internet

http://journal.frontiersin.org/article/10.3389/fimmu.2017.00450/full

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