Gremlin Regulates Tubular Epithelial to Mesenchymal Transition via VEGFR2: Potential Role in Renal Fibrosis

Gremlin Regulates Tubular Epithelial to Mesenchymal Transition via VEGFR2: Potential Role in Renal Fibrosis

Chronic kidney disease (CKD) is emerging as an important health problem due to the increase number of CKD patients and the absence of an effective curative treatment. Gremlin has been proposed as a novel therapeutic target for renal inflammatory diseases, acting via Vascular Endothelial Growth Facto...

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Bibliographic Details
Main Authors: Laura Marquez-Exposito, Carolina Lavoz, Raul R. Rodrigues-Diez, Sandra Rayego-Mateos, Macarena Orejudo, Elena Cantero-Navarro, Alberto Ortiz, Jesús Egido, Rafael Selgas, Sergio Mezzano, Marta Ruiz-Ortega
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-10-01
Series:Frontiers in Pharmacology
Subjects:
gremlin
VEGFR2
notch
EMT
tubular cells
fibrosis
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2018.01195/full

Internet

https://www.frontiersin.org/article/10.3389/fphar.2018.01195/full

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