Ventral hippocampal projections to the medial prefrontal cortex regulate social memory

Inputs from the ventral hippocampus (vHIP) to the medial prefrontal cortex (mPFC) are implicated in several neuropsychiatric disorders. Here, we show that the vHIP-mPFC projection is hyperactive in the Mecp2 knockout mouse model of the autism spectrum disorder Rett syndrome, which has deficits in so...

Full description

Bibliographic Details
Main Authors: Mary L Phillips, Holly Anne Robinson, Lucas Pozzo-Miller
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2019-05-01
Series:eLife
Subjects:
Online Access:https://elifesciences.org/articles/44182