Divergent Expression and Metabolic Functions of Human Glucuronosyltransferases through Alternative Splicing

Divergent Expression and Metabolic Functions of Human Glucuronosyltransferases through Alternative Splicing

Maintenance of cellular homeostasis and xenobiotic detoxification is mediated by 19 human UDP-glucuronosyltransferase enzymes (UGTs) encoded by ten genes that comprise the glucuronidation pathway. Deep RNA sequencing of major metabolic organs exposes a substantial expansion of the UGT transcriptome...

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Bibliographic Details
Main Authors: Michèle Rouleau, Alan Tourancheau, Camille Girard-Bock, Lyne Villeneuve, Jonathan Vaucher, Anne-Marie Duperré, Yannick Audet-Delage, Isabelle Gilbert, Ion Popa, Arnaud Droit, Chantal Guillemette
Format: Article
Language:English
Published: Elsevier 2016-09-01
Series:Cell Reports
Subjects:
Glucuronosyltransferase (UGT)
glucuronidation
drug metabolism
cell metabolism
RNA sequencing
alternative splicing
transcriptome
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124716311731

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http://www.sciencedirect.com/science/article/pii/S2211124716311731

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