Anti-TNF Alpha Antibody Humira with pH-Dependent Binding Characteristics: A Constant-pH Molecular Dynamics, Gaussian Accelerated Molecular Dynamics, and In Vitro Study

Humira is a monoclonal antibody that binds to TNF alpha, inactivates TNF alpha receptors, and inhibits inflammation. Neonatal Fc receptors can mediate the transcytosis of Humira–TNF alpha complex structures and process them toward degradation pathways, which reduces the therapeutic effect of Humira....

Full description

Bibliographic Details
Main Authors: Shih-Ting Hong, Yu-Cheng Su, Yu-Jen Wang, Tian-Lu Cheng, Yeng-Tseng Wang
Format: Article
Language:English
Published: MDPI AG 2021-02-01
Series:Biomolecules
Subjects:
Online Access:https://www.mdpi.com/2218-273X/11/2/334