BRD4 bimodal binding at promoters and drug-induced displacement at Pol II pause sites associates with I-BET sensitivity

BRD4 bimodal binding at promoters and drug-induced displacement at Pol II pause sites associates with I-BET sensitivity

Abstract Background Deregulated transcription is a major driver of diseases such as cancer. Bromodomain and extra-terminal (BET) proteins (BRD2, BRD3, BRD4 and BRDT) are chromatin readers essential for maintaining proper gene transcription by specifically binding acetylated lysine residues. Targeted...

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Bibliographic Details
Main Authors: P. Khoueiry, A. Ward Gahlawat, M. Petretich, A. M. Michon, D. Simola, E. Lam, E. E. Furlong, V. Benes, M. A. Dawson, R. K. Prinjha, G. Drewes, P. Grandi
Format: Article
Language:English
Published: BMC 2019-07-01
Series:Epigenetics & Chromatin
Subjects:
Bromodomain proteins
Sensitivity and resistance to drug treatment
Regulatory regions
Promoters
TSS
Leukemia
Online Access:http://link.springer.com/article/10.1186/s13072-019-0286-5

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http://link.springer.com/article/10.1186/s13072-019-0286-5

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