Functional relevance of the multi-drug transporter abcg2 on teriflunomide therapy in an animal model of multiple sclerosis

Functional relevance of the multi-drug transporter abcg2 on teriflunomide therapy in an animal model of multiple sclerosis

Abstract Background The multi-drug resistance transporter ABCG2, a member of the ATP-binding cassette (ABC) transporter family, mediates the efflux of different immunotherapeutics used in multiple sclerosis (MS), e.g., teriflunomide (teri), cladribine, and mitoxantrone, across cell membranes and org...

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Bibliographic Details
Main Authors: Lisa Thiele née Schrewe, Kirsten Guse, Silvia Tietz, Jana Remlinger, Seray Demir, Xiomara Pedreiturria, Robert Hoepner, Anke Salmen, Maximilian Pistor, Timothy Turner, Britta Engelhardt, Dirk M. Hermann, Fred Lühder, Stefan Wiese, Andrew Chan
Format: Article
Language:English
Published: BMC 2020-01-01
Series:Journal of Neuroinflammation
Subjects:
abcg2
Teriflunomide
Multiple sclerosis
Experimental autoimmune encephalomyelitis
Online Access:https://doi.org/10.1186/s12974-019-1677-z

Internet

https://doi.org/10.1186/s12974-019-1677-z

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