CD47-SIRPα Checkpoint Inhibition Enhances Neutrophil-Mediated Killing of Dinutuximab-Opsonized Neuroblastoma Cells

CD47-SIRPα Checkpoint Inhibition Enhances Neutrophil-Mediated Killing of Dinutuximab-Opsonized Neuroblastoma Cells

High-risk neuroblastoma, especially after recurrence, still has a very low survival rate. Immune checkpoint inhibitors targeting T cells have shown remarkable clinical efficacy in adult solid tumors, but their effects in pediatric cancers have been limited so far. On the other hand, targeting myeloi...

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Bibliographic Details
Main Authors: Paula Martínez-Sanz, Arjan J. Hoogendijk, Paul J. J. H. Verkuijlen, Karin Schornagel, Robin van Bruggen, Timo K. van den Berg, Godelieve A. M. Tytgat, Katka Franke, Taco W. Kuijpers, Hanke L. Matlung
Format: Article
Language:English
Published: MDPI AG 2021-08-01
Series:Cancers
Subjects:
neutrophils
neuroblastoma
dinutuximab
antibody-dependent cellular cytotoxicity
antibody therapy
checkpoint blockade
Online Access:https://www.mdpi.com/2072-6694/13/17/4261

Internet

https://www.mdpi.com/2072-6694/13/17/4261

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