Neuropilin-1 Expression Associates with Poor Prognosis in HNSCC and Elicits EGFR Activation upon CDDP-Induced Cytotoxic Stress

Neuropilin-1 Expression Associates with Poor Prognosis in HNSCC and Elicits EGFR Activation upon CDDP-Induced Cytotoxic Stress

Head and neck squamous cell carcinoma (HNSCC) includes a group of aggressive malignancies characterized by the overexpression of the epidermal growth factor receptor (EGFR) in 90% of cases. Neuropilin-1 (NRP-1) acts as an EGFR co-receptor, enhancing, upon ligand stimulation, EGFR signaling in severa...

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Bibliographic Details
Main Authors: Virginia Napolitano, Daniela Russo, Francesco Morra, Francesco Merolla, Silvia Varricchio, Gennaro Ilardi, Rosa Maria Di Crescenzo, Francesco Martino, Massimo Mascolo, Angela Celetti, Luca Tamagnone, Stefania Staibano
Format: Article
Language:English
Published: MDPI AG 2021-07-01
Series:Cancers
Subjects:
NRP-1
EGFR
HNSCC
cisplatin
Online Access:https://www.mdpi.com/2072-6694/13/15/3822

Internet

https://www.mdpi.com/2072-6694/13/15/3822

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