Detection of microbial cell-free DNA in maternal and umbilical cord plasma in patients with chorioamnionitis using next generation sequencing.

BACKGROUND:Chorioamnionitis has been linked to spontaneous preterm labor and complications such as neonatal sepsis. We hypothesized that microbial cell-free (cf) DNA would be detectable in maternal plasma in patients with chorioamnionitis and could be the basis for a non-invasive method to detect fe...

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Bibliographic Details
Main Authors: Russell G Witt, Lily Blair, Michela Frascoli, Michael J Rosen, Quoc-Hung Nguyen, Sivan Bercovici, Simona Zompi, Roberto Romero, Tippi C Mackenzie
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2020-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0231239