Prolactin Alters the Mammary Epithelial Hierarchy, Increasing Progenitors and Facilitating Ovarian Steroid Action

Prolactin Alters the Mammary Epithelial Hierarchy, Increasing Progenitors and Facilitating Ovarian Steroid Action

Hormones drive mammary development and function and play critical roles in breast cancer. Epidemiologic studies link prolactin (PRL) to increased risk for aggressive cancers that express estrogen receptor α (ERα). However, in contrast to ovarian steroids, PRL actions on the mammary gland outside of...

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Bibliographic Details
Main Authors: Kathleen A. O'Leary, Michael P. Shea, Stephanie Salituro, Courtney E. Blohm, Linda A. Schuler
Format: Article
Language:English
Published: Elsevier 2017-10-01
Series:Stem Cell Reports
Subjects:
prolactin
mammary epithelial cell subpopulations
mammary stem cells
luminal progenitors
breast cancer
luminal subtype
ER+ breast cancer
Online Access:http://www.sciencedirect.com/science/article/pii/S2213671117303685

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http://www.sciencedirect.com/science/article/pii/S2213671117303685

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