Disease Animal Models of TDP-43 Proteinopathy and Their Pre-Clinical Applications

Disease Animal Models of TDP-43 Proteinopathy and Their Pre-Clinical Applications

Frontotemperal lobar degeneration (FTLD) and amyotrophic lateral sclerosis (ALS) are two common neurodegenerative diseases. TDP-43 is considered to be a major disease protein in FTLD/ALS, but it’s exact role in the pathogenesis and the effective treatments remains unknown. To address this question a...

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Bibliographic Details
Main Authors: Kuen-Jer Tsai, Po-Min Chiang, Yu-Chih Liu
Format: Article
Language:English
Published: MDPI AG 2013-10-01
Series:International Journal of Molecular Sciences
Subjects:
amyotrophic lateral sclerosis
disease models
frontotemperal lobar degeneration
proteinopathy
TDP-43
therapy
Online Access:http://www.mdpi.com/1422-0067/14/10/20079

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http://www.mdpi.com/1422-0067/14/10/20079

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