Cordycepin Down-Regulates Multiple Drug Resistant (MDR)/HIF-1α through Regulating AMPK/mTORC1 Signaling in GBC-SD Gallbladder Cancer Cells

Cordycepin Down-Regulates Multiple Drug Resistant (MDR)/HIF-1α through Regulating AMPK/mTORC1 Signaling in GBC-SD Gallbladder Cancer Cells

Gallbladder cancer is the most common malignancy of the bile duct, with low 5-year survival rate and poor prognosis. Novel effective treatments are urgently needed for the therapy of this disease. Here, we showed that cordycepin, the bioactive compound in genus Cordyceps, induced growth inhibition...

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Bibliographic Details
Main Authors: Wei-Ding Wu, Zhi-Ming Hu, Min-Jie Shang, Da-Jian Zhao, Cheng-Wu Zhang, De-Fei Hong, Dong-Sheng Huang
Format: Article
Language:English
Published: MDPI AG 2014-07-01
Series:International Journal of Molecular Sciences
Subjects:
the gallbladder cancer
cordycepin
AMPK
multiple drug resistant (MDR)
HIF-1α
mTORC1 and chemo-sensitization
Online Access:http://www.mdpi.com/1422-0067/15/7/12778

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http://www.mdpi.com/1422-0067/15/7/12778

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