Mind the gaps: overlooking inaccessible regions confounds statistical testing in genome analysis

Mind the gaps: overlooking inaccessible regions confounds statistical testing in genome analysis

Abstract Background The current versions of reference genome assemblies still contain gaps represented by stretches of Ns. Since high throughput sequencing reads cannot be mapped to those gap regions, the regions are depleted of experimental data. Moreover, several technology platforms assay a targe...

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Bibliographic Details
Main Authors: Diana Domanska, Chakravarthi Kanduri, Boris Simovski, Geir Kjetil Sandve
Format: Article
Language:English
Published: BMC 2018-12-01
Series:BMC Bioinformatics
Subjects:
Assembly gaps
Reference genome
Statistical genome analysis
Colocalization analysis
Co-occurrence analysis
Region set enrichment analysis
Online Access:http://link.springer.com/article/10.1186/s12859-018-2438-1

Internet

http://link.springer.com/article/10.1186/s12859-018-2438-1

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