Inhibition of kras-derived exosomes downregulates immunosuppressive BACH2/GATA-3 expression via RIP-3 dependent necroptosis and miR-146/miR-210 modulation

Inhibition of kras-derived exosomes downregulates immunosuppressive BACH2/GATA-3 expression via RIP-3 dependent necroptosis and miR-146/miR-210 modulation

Immunosuppressive chemoresistance is a major challenge in lung cancer treatment. Exosomes present in the tumor microenviroment are implicated in chemoresistant-related immune suppression, and metastasis but the exact pathogenic role of lung-derived exosomes is still uncertain. Recent reports reveal...

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Bibliographic Details
Main Authors: Savvas Petanidis, Kalliopi Domvri, Konstantinos Porpodis, Doxakis Anestakis, Lutz Freitag, Wolfgang Hohenforst-Schmidt, Drosos Tsavlis, Konstantinos Zarogoulidis
Format: Article
Language:English
Published: Elsevier 2020-02-01
Series:Biomedicine & Pharmacotherapy
Subjects:
Kras
Exosomes
BACH2
Necroptosis
miR-146/miR-210
Online Access:http://www.sciencedirect.com/science/article/pii/S0753332219334808

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http://www.sciencedirect.com/science/article/pii/S0753332219334808

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