FK506 Attenuates the MRP1-Mediated Chemoresistant Phenotype in Glioblastoma Stem-Like Cells

FK506 Attenuates the MRP1-Mediated Chemoresistant Phenotype in Glioblastoma Stem-Like Cells

Poor response to current treatments for glioblastoma has been attributed to the presence of glioblastoma stem-like cells (GSCs). GSCs are able to expel antitumor drugs to the extracellular medium using the multidrug resistance-associated protein 1 (MRP1) transporter. Tacrolimus (FK506) has been iden...

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Bibliographic Details
Main Authors: Ángelo Torres, Valentina Arriagada, José Ignacio Erices, María de los Ángeles Toro, José Dellis Rocha, Ignacio Niechi, Cristian Carrasco, Carlos Oyarzún, Claudia Quezada
Format: Article
Language:English
Published: MDPI AG 2018-09-01
Series:International Journal of Molecular Sciences
Subjects:
ATP-binding cassette transporter
glioblastoma stem-like cells
multiple drug resistance
multidrug resistance-associated protein 1
tacrolimus
Online Access:http://www.mdpi.com/1422-0067/19/9/2697

Internet

http://www.mdpi.com/1422-0067/19/9/2697

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