BK channel inactivation gates daytime excitability in the circadian clock
BK potassium channels have been previously shown to mediate SCN circadian firing, although the precise mechanisms are unclear. Here, using knockout and rescue approaches, the authors find that the ß2 ‘ball-and-chain’ confers BK channel inactivation during the day, promoting SCN electrical upstate....
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Publishing Group
2016-03-01
|
| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/ncomms10837 |