BK channel inactivation gates daytime excitability in the circadian clock

BK potassium channels have been previously shown to mediate SCN circadian firing, although the precise mechanisms are unclear. Here, using knockout and rescue approaches, the authors find that the ß2 ‘ball-and-chain’ confers BK channel inactivation during the day, promoting SCN electrical upstate....

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Main Authors:	Joshua P. Whitt, Jenna R. Montgomery, Andrea L. Meredith
Format:	Article
Language:	English
Published:	Nature Publishing Group 2016-03-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/ncomms10837

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spelling	doaj-71b72ebbc6e9459fb23474859a7f793f2021-05-11T10:49:07ZengNature Publishing GroupNature Communications2041-17232016-03-017111310.1038/ncomms10837BK channel inactivation gates daytime excitability in the circadian clockJoshua P. Whitt0Jenna R. Montgomery1Andrea L. Meredith2Department of Physiology, University of Maryland School of MedicineDepartment of Physiology, University of Maryland School of MedicineDepartment of Physiology, University of Maryland School of MedicineBK potassium channels have been previously shown to mediate SCN circadian firing, although the precise mechanisms are unclear. Here, using knockout and rescue approaches, the authors find that the ß2 ‘ball-and-chain’ confers BK channel inactivation during the day, promoting SCN electrical upstate.https://doi.org/10.1038/ncomms10837
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Joshua P. Whitt Jenna R. Montgomery Andrea L. Meredith
spellingShingle	Joshua P. Whitt Jenna R. Montgomery Andrea L. Meredith BK channel inactivation gates daytime excitability in the circadian clock Nature Communications
author_facet	Joshua P. Whitt Jenna R. Montgomery Andrea L. Meredith
author_sort	Joshua P. Whitt
title	BK channel inactivation gates daytime excitability in the circadian clock
title_short	BK channel inactivation gates daytime excitability in the circadian clock
title_full	BK channel inactivation gates daytime excitability in the circadian clock
title_fullStr	BK channel inactivation gates daytime excitability in the circadian clock
title_full_unstemmed	BK channel inactivation gates daytime excitability in the circadian clock
title_sort	bk channel inactivation gates daytime excitability in the circadian clock
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2016-03-01
description	BK potassium channels have been previously shown to mediate SCN circadian firing, although the precise mechanisms are unclear. Here, using knockout and rescue approaches, the authors find that the ß2 ‘ball-and-chain’ confers BK channel inactivation during the day, promoting SCN electrical upstate.
url	https://doi.org/10.1038/ncomms10837
work_keys_str_mv	AT joshuapwhitt bkchannelinactivationgatesdaytimeexcitabilityinthecircadianclock AT jennarmontgomery bkchannelinactivationgatesdaytimeexcitabilityinthecircadianclock AT andrealmeredith bkchannelinactivationgatesdaytimeexcitabilityinthecircadianclock
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BK channel inactivation gates daytime excitability in the circadian clock

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