MAPKAP Kinase-2 Drives Expression of Angiogenic Factors by Tumor-Associated Macrophages in a Model of Inflammation-Induced Colon Cancer

MAPKAP Kinase-2 Drives Expression of Angiogenic Factors by Tumor-Associated Macrophages in a Model of Inflammation-Induced Colon Cancer

Chronic inflammation increases the risk for colorectal cancer through a variety of mechanisms involving the tumor microenvironment. MAPK-activated protein kinase 2 (MK2), a major effector of the p38 MAPK stress and DNA damage response signaling pathway, and a critical regulator of pro-inflammatory c...

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Bibliographic Details
Main Authors: Lucia Suarez-Lopez, Yi Wen Kong, Ganapathy Sriram, Jesse C. Patterson, Samantha Rosenberg, Sandra Morandell, Kevin M. Haigis, Michael B. Yaffe
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-02-01
Series:Frontiers in Immunology
Subjects:
signal transduction
MAPKAP kinase 2
tumor associated macrophage (TAM)
inflammation driven tumorigenesis
colon tumors
stress signaling
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2020.607891/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2020.607891/full

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