Chymase-Cre; Mcl-1fl/fl Mice Exhibit Reduced Numbers of Mucosal Mast Cells

Chymase-Cre; Mcl-1fl/fl Mice Exhibit Reduced Numbers of Mucosal Mast Cells

Mast cells (MCs) are considered as key effector cells in the elicitation of allergic symptoms, and they are essential players in innate and adaptive immune responses. In mice, two main types of MCs have been described: connective tissue MCs (CTMCs) and mucosal MCs (MMCs). However, little is known ab...

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Bibliographic Details
Main Authors: Ying Luo, Nicole Meyer, Qingqing Jiao, Jörg Scheffel, Carolin Zimmermann, Martin Metz, Ana Zenclussen, Marcus Maurer, Frank Siebenhaar
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-10-01
Series:Frontiers in Immunology
Subjects:
mast cells
mouse model
mucosa
connective tissue
chymase
Cre
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.02399/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2019.02399/full

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