Intracerebral Administration of a Ligand-ASO Conjugate Selectively Reduces α-Synuclein Accumulation in Monoamine Neurons of Double Mutant Human A30P*A53T*α-Synuclein Transgenic Mice

Intracerebral Administration of a Ligand-ASO Conjugate Selectively Reduces α-Synuclein Accumulation in Monoamine Neurons of Double Mutant Human A30P*A53T*α-Synuclein Transgenic Mice

α-Synuclein (α-Syn) protein is involved in the pathogenesis of Parkinson’s disease (PD). Point mutations and multiplications of the α-Syn, which encodes the <i>SNCA</i> gene, are correlated with early-onset PD, therefore the reduction in a-Syn synthesis could be a potential therapy for P...

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Bibliographic Details
Main Authors: Rubén Pavia-Collado, Valentín Cóppola-Segovia, Lluís Miquel-Rio, Diana Alarcón-Aris, Raquel Rodríguez-Aller, María Torres-López, Verónica Paz, Esther Ruiz-Bronchal, Leticia Campa, Francesc Artigas, Andrés Montefeltro, Raquel Revilla, Analia Bortolozzi
Format: Article
Language:English
Published: MDPI AG 2021-03-01
Series:International Journal of Molecular Sciences
Subjects:
α-synuclein
antisense oligonucleotide
dopamine neurotransmission
double mutant A30P*A53T*
motor deficits
Parkinson’s disease
Online Access:https://www.mdpi.com/1422-0067/22/6/2939

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https://www.mdpi.com/1422-0067/22/6/2939

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