Mechanistic Study of the Spiroindolones: A New Class of Antimalarials

Mechanistic Study of the Spiroindolones: A New Class of Antimalarials

During the synthesis of the new antimalarial drug candidate NITD609, a high degree of diastereoselectivity was observed in the Pictet-Spengler reaction. By isolating both the <strong>4<em>E</em></strong> and <strong>4<em&am...

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Bibliographic Details
Main Authors: Thomas H. Keller, Bryan K. S. Yeung, Louis-Sebastian Sonntag, Seh Yong Leong, Peiling Yap, Bin Zou
Format: Article
Language:English
Published: MDPI AG 2012-08-01
Series:Molecules
Subjects:
malaria
spiroindolones
NITD609
Pictet-Spengler reaction
mechanism
Online Access:http://www.mdpi.com/1420-3049/17/9/10131

Internet

http://www.mdpi.com/1420-3049/17/9/10131

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