Elevated myocardial fructose and sorbitol levels are associated with diastolic dysfunction in diabetic patients, and cardiomyocyte lipid inclusions in vitro

Elevated myocardial fructose and sorbitol levels are associated with diastolic dysfunction in diabetic patients, and cardiomyocyte lipid inclusions in vitro

Abstract Diabetes is associated with cardiac metabolic disturbances and increased heart failure risk. Plasma fructose levels are elevated in diabetic patients. A direct role for fructose involvement in diabetic heart pathology has not been investigated. The goals of this study were to clinically eva...

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Bibliographic Details
Main Authors: Lorna J. Daniels, Marco Annandale, Parisa Koutsifeli, Xun Li, Carol T. Bussey, Isabelle van Hout, Richard W. Bunton, Philip J. Davis, Sean Coffey, Rajesh Katare, Regis R. Lamberts, Lea M. D. Delbridge, Kimberley M. Mellor
Format: Article
Language:English
Published: Nature Publishing Group 2021-02-01
Series:Nutrition & Diabetes
Online Access:https://doi.org/10.1038/s41387-021-00150-7

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https://doi.org/10.1038/s41387-021-00150-7

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