PD-1 blockade restores impaired function of ex vivo expanded CD8+ T cells and enhances apoptosis in mismatch repair deficient EpCAM+PD-L1+ cancer cells

PD-1 blockade restores impaired function of ex vivo expanded CD8+ T cells and enhances apoptosis in mismatch repair deficient EpCAM+PD-L1+ cancer cells

Rajeev Kumar,1,2 Fang Yu,1 Yuan-Huan Zhen,3 Bo Li,2 Jun Wang,1 Yuan Yang,1,2 Hui-Xin Ge,4 Ping-Sheng Hu,1,2 Jin Xiu1,2 1Clinical Research Centre, The Affiliated Hospital of Guizhou Medical University, Guiyang, People’s Republic of China; 2Cancer Immunology and Immunotherapy Centre, The A...

Full description

Bibliographic Details
Main Authors: Kumar R, Yu F, Zhen YH, Li B, Wang J, Yang Y, Ge HX, Hu P, Xiu J
Format: Article
Language:English
Published: Dove Medical Press 2017-07-01
Series:OncoTargets and Therapy
Subjects:
PD-1
CTLs
MSI-H
EpCAM+PDL-1+
Cancer Immunotherapy
Online Access:https://www.dovepress.com/pd-1-blockade-restores-impaired-function-of-ex-vivo-expanded-cd8-t-cel-peer-reviewed-article-OTT

Internet

https://www.dovepress.com/pd-1-blockade-restores-impaired-function-of-ex-vivo-expanded-cd8-t-cel-peer-reviewed-article-OTT

Similar Items