Efficacy of GC-376 against SARS-CoV-2 virus infection in the K18 hACE2 transgenic mouse model

Efficacy of GC-376 against SARS-CoV-2 virus infection in the K18 hACE2 transgenic mouse model

Abstract The COVID-19 pandemic caused by the Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) is the defining global health emergency of this century. GC-376 is a Mpro inhibitor with antiviral activity against SARS-CoV-2 in vitro. Using the K18-hACE2 mouse model, the in vivo antiviral ef...

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Bibliographic Details
Main Authors: C. Joaquín Cáceres, Stivalis Cardenas-Garcia, Silvia Carnaccini, Brittany Seibert, Daniela S. Rajao, Jun Wang, Daniel R. Perez
Format: Article
Language:English
Published: Nature Publishing Group 2021-05-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-021-89013-w

Internet

https://doi.org/10.1038/s41598-021-89013-w

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