Possible Involvement of Sphingosine-1-Phosphate/Gi/RhoA Pathways in Adherence of Eosinophils to Pulmonary Endothelium

Possible Involvement of Sphingosine-1-Phosphate/Gi/RhoA Pathways in Adherence of Eosinophils to Pulmonary Endothelium

Background: Sphingosine-1-phosphate (S1P), a lysophospholipid released from inflammatory cells, causes cell migration by increasing cytokines and chemokines. This study was designed to determine whether S1P causes adherence of eosinophils to pulmonary endothelial cells via enhancement of adhesion mo...

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Bibliographic Details
Main Authors: Toyokazu Sashio, Hiroaki Kume, Naoya Takeda, Toshiaki Asano, Seita Tsuji, Masashi Kondo, Yoshinori Hasegawa, Kaoru Shimokata
Format: Article
Language:English
Published: Elsevier 2012-01-01
Series:Allergology International
Subjects:
asthma
eosinophils
lipid mediators
pertussis toxin-sensitive G protein
Rho-kinase
small G protein
VCAM-1
Y-27632
Online Access:http://www.sciencedirect.com/science/article/pii/S1323893015302227

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http://www.sciencedirect.com/science/article/pii/S1323893015302227

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