Ex Vivo Expanded Human Non-Cytotoxic CD8+CD45RClow/− Tregs Efficiently Delay Skin Graft Rejection and GVHD in Humanized Mice

Ex Vivo Expanded Human Non-Cytotoxic CD8+CD45RClow/− Tregs Efficiently Delay Skin Graft Rejection and GVHD in Humanized Mice

Both CD4+ and CD8+ Tregs play a critical role in the control of immune responses and immune tolerance; however, our understanding of CD8+ Tregs is limited while they are particularly promising for therapeutic application. We report here existence of highly suppressive human CD8+CD45RClow/− Tregs exp...

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Bibliographic Details
Main Authors: Séverine Bézie, Dimitri Meistermann, Laetitia Boucault, Stéphanie Kilens, Johanna Zoppi, Elodie Autrusseau, Audrey Donnart, Véronique Nerrière-Daguin, Frédérique Bellier-Waast, Eric Charpentier, Franck Duteille, Laurent David, Ignacio Anegon, Carole Guillonneau
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-01-01
Series:Frontiers in Immunology
Subjects:
transplantation
tolerance
Treg
cell therapy
graft
GVHD
Online Access:http://journal.frontiersin.org/article/10.3389/fimmu.2017.02014/full

Internet

http://journal.frontiersin.org/article/10.3389/fimmu.2017.02014/full

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